Scientific Program

Day 1 :

Keynote Forum

Dr. Jennie M. Bennett

Director at Reconstruction of a Survivor, USA

Keynote: The Forgotten Aspect of Survivorship

Time : 10:00

Biography:

Abstract:

Problem:

When a woman is diagnosed with breast cancer the major aspect of treatment and survivorship is physical. What are the treatment options? Will I live or die? What if I don’t have insurance? These are only a few challenges facing women diagnosed with breast cancer. However, there is another component of the diagnosis that is pivotal to treatment- the psycho-social healing. Research states that people diagnosed with a serious disease or illness gravitate toward their faith. This is a strong component of treatment that can’t be overlooked.

The Approach:

Navigating the Roadmap to Survivorship includes the emotional and spiritual wellbeing of the patient with breast cancer. Medical staff do not have ample time to address the role psycho social treatment plays in the treatment of breast cancer. Moreover, the patient may not be aware that she is having emotional challenges during this part of life’s journey. Therefore, support groups play a pivotal role in the treatment of breast cancer patients.

Conclusion:

Reconstruction of a Survivor was founded to provide that missing link beyond the physical treatment of breast cancer. Reconstruction of a Survivor provides a 26-session curriculum designed to address the challenges women encounter when diagnosed with breast cancer. This transportable curriculum has benefited thousands of women so they experience emotional and spiritual support and healing as they journey through a diagnosis of breast cancer.

 

  • Breast Cancer Screening

Session Introduction

Stefano Pacifici

Lecturer at Sapienza University of Rome. Italy

Title: ASSESSING OF THE “RISK OF PAIN” IN MAMMOGRAPHY
Speaker
Biography:

Abstract:

PURPOSE

Mammography is an important tool in the secondary prevention of breast cancer. However, according to literature, a wide percentage of women reports pain or discomfort during the procedure that may undermine compliance with periodic or follow-up mammography.

The study focuses firstly on identifying the factors that determine the risk of pain during the mammography procedure with special attention to the woman-related factors, the examination context, the procedure itself and the screening staff; secondly, it sets out to define recommendations to reduce the pain experienced during mammography.

METHODS AND MATERIALS

300 women >40 years were interviewed immediately before and after undergoing mammography.

Pre-test interview was used to evaluate the expected pain and the risk factors. Subsequently, after an appropriate counselling and the given option over the control of the compression force, mammography was performed.

In post-test interview the women were asked about the pain experienced, the difference between what experienced and their preliminary expectation, and the most stressful moment of the entire procedure.

RESULTS

Study results showed a number of women-related, staff-related and procedural-relate factors considered significant in the assessing of the risk of pain, besides anticipatory anxiety related to a possible positive diagnosis.

Anticipation of pain and discomfort were the dominant factor explaining a pain experience, except for women at their first mammography. For these women seems to be crucial the staff behaviour, even more for those at their follow-up mammogram, in addition to anticipatory anxiety. Despite the most of assessed women expected that mammography would be painful, most of those who anticipated pain has reported that the severity of pain experienced during current test was much lower than how it was anticipated, except from women with breast cyclic pain.

CONCLUSIONS

These data serve to emphasize the need for a careful assessment of the emotional status of the woman and an appropriate pre-mammography counselling, to address those factors which may interfere with future adherence and compliance.

Interventions include an empathetic and supportive breast radiographer behaviour.

In the circumstances that previous mammography was very painful, or it is known that the participant has sensitive breasts, additional care should be taken by offering women the chance to control the pressure themselves, as earlier studies showed that this measure is effective without compromising image quality.

  • Current perspective of Breast Cancer
Biography:

Abstract:

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc.

My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds   that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry ,  especially    Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron,  Nickel, Zinc, Cadmium etc.

The main emphasis of my talk would be on Different class of Ligands, their Schiff’s Bases and Transition Metal Complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as Anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing Binding sites and diverse strategies employed by my group for elucidation of Anti-Cancer and Anti-HIV drug Leads to Circumvent the problem caused by Cis-Platin.

We have synthesized and characterized several phytochemicals from Traditional Medicinal Plants and isolated some phytochemicals and  made the corresponding Oximes, Thiosemicarbazones and Substituted thiosemicarbazones as ligands and synthesized, characterized, structurally

KALINIJABO Yves

University of Rwanda, College of Science and Technology, Rwanda

Title: Epidemiology and Clinical features of breast cancer in Rwanda
Speaker
Biography:

Abstract:

Background and Objectives: Breast cancer is a growing crisis in the developing world. With a majority of breast cancer deaths occurring in the low income countries including Rwanda. The objective of this analytical study is to assess the epidemiology and clinical features of breast cancer in Rwanda.

Methods: Data were collected from August 2015 to January 2017 by considering information recorded from Out Patients Department (OPD), surgery and laboratory log books and from the archives of patients tested and diagnosed with breast cancer from three referral hospitals. Microsoft Excel and Statistical Packages for Social Sciences (SPSS 19.0) have been used for data entry and analysis.

Results: Brest cancer incidence rate frequency from August 2015 to January 2017 was 33.33% per semester. Amid the diagnosed breast cancer cases in that period, 97.04% of all cases arise in female whereas 2.87% arise in male. The most frequent breast cancer type was invasive ductal carcinoma with 80.43% and the least common were mucinous carcinoma and infiltrating medullary carcinoma with 1.08% for each. According to the age, both male and female between 51 and 60 years old are more likely to be affected with a frequency of 31.73%.

Discussion and Conclusion: Breast cancer frequency is increasing, because patients do not go for diagnosis and the few patients who go for it, are late and breast cancer is already advanced. Therefore we recommend to increase the awareness of breast cancer but also further researches to find affordable ways of breast cancer detection at early stages, for example we have started a research on rapid tests for breast cancer detection.

 

 

  • Women Wellness

Session Introduction

Izquierdo M, Browne

Breast Cancer Unit. Dexeus University Hospital.Spain

Title: Mammographic Breast Density: its role in tumor size assessment with imaging techniques.
Biography:

Abstract:

Aims: To study the visual and automatic measurement of mammographic breast density (MBD) and its implications in tumor size assessment using distinct imaging techniques.

Methods: Study of the visual and automatic measurement of mammographic breast density according to the breast imaging data system (BI-RADS) in 212 patients with invasive unifocal breast cancer, excluding microinvasive lesions, who did not receive neoadjuvant chemotherapy.

Tumor size assessment was compared using a linear regression according pathologic size with mammographic, US and MR size. The influence of MBD in each technique of pathologic size was seen by Bland-Altman plot.

Results:

Patient’s mean age was 55,7±9.9 year-old.

The mean size of the lesion stablished by mammography was 16.8± 10.4 (4 -70) mm, by US was 13.6±7.2 (5 – 55) mm and by MR 17.2 ±9.9 (5 – 66) mm.  Mean pathologic size was 12.6 ±8.1 (0.3 – 55) mm.

Automatic MBD mean was 25.2±16.78. BIRAD assessment with visual and automatic MBD measurements were correlated with a tendency of tumor size overestimation with visual method (Table 1).

Linear regression of tumor size according image techniques with pathologic size showed an adjusted r-square of 27.3% for mammography (Fig 1), 41.8% for US (Fig. 2) and 51.7% for MR (Fig. 3). The best correlation was seen with MR although has a tendency to overestimate tumor size. Only tumor size assessed by mammography was influenced by MBD. With this technique, tumor size was best adjusted for those breasts with lower MBD.

Conclusion: Visual measurement overestimates MBD versus automatic measurement according BIRADS categories. MR is the more accurate breast imaging technique for assessing tumor size independently of the BMD which only influences in the mammographic tumor size estimation.

  • Causes & Care of Breast Cancer
Speaker
Biography:

Abstract:

Breast cancer is a real public health problem in Cameroon, where more patients with this cancer usually die a year after diagnosis, as it is still based on histological examination, mortality due to cancer is far from decreasing. Since cancer is an accumulation of molecular changes, the +331 G/A polymorphism of PgR gene (progesterone receptor) and viral oncogene HMTV (Human Mammary Tumor Virus) has been recently considered as a molecular markers associated with breast cancer. Due to that we fixed our objectives to characterize these markers. We carried out a case control study, in which 26 cases diagnosed positive for breast cancer at the CHU of Yaounde were recruited through the identification of archived biopsies. Blood samples were also collected from 20 women recruited using a questionnaire and a inform concern sign by each of them. +331 G/A polymorphism in the PgR gene was identified using NIaIV endonuclease by PCR-RFLP, and HMTV viral oncogene by hemie-nested PCR. The data were analyzed using Microsoft Excel and SPSS v20. We got a mean age of 57,73 +/- 9,87 in our cancerous group with the predominance of infiltrant duct carcinoma at grade II of SBR. An Odd Ratio of 1.268 with Confident Interval of 95% 1.004-1.664 proving that there is a significant association between 331G/A mutation and breast cancer with P-value of 0.026, obtained by comparing the mutant group (AA) 28,5% and wild genotype (GG). In addition, 3 cases were detected with the HMTV virus, one was found in the cancer group and two in the control group. These results indicate that, HMTV is considered as viral cause and can predispose to breast cancer, beside 331 G/A polymorphism is an associated risk factor of that cancer.

  • Rehabilitation of Breast Cancer

Session Introduction

Dr. Wook Song

Professor at Seoul National University, KOREA

Title: High-intensity interval training for Korean breast cancer survivors: A pilot study
Speaker
Biography:

Abstract:

Background: Recently, growing evidences support that low and moderate intensity exercise can alleviate deleterious effects from breast cancer surgery. Many cancer survivors may participate in exercise program; however, there is a lack of evidence regarding the feasibility and relevance of high intensity interval training for breast cancer survivors. Therefore, this study was conducted to develop a high intensity interval training for breast cancer survivors in Korea and to confirm its feasibility.

Methods: Survey was performed on the subjects who had participated in 2015 Pink Ribbon campaign. The survey focused on the overall thoughts regarding the exercise they participated and 84 out of 100 surveys were collected. The program was executed for 4 weeks on 13 subjects whose breast cancer treatment had been terminated for more than 2 years. The exercise program consisted of 10 min-foam roller stretch, 40 min-circuit exercise (3 sessions total, each consisted of 10 exercises and 15 sec resting), and 10 min-cool-down exercise for the total of 60 min twice a week.

Results: To examine the feasibility of the high-intensity interval training program, the attendance rate was recorded and the subjects’ heart rate during exercise was checked by Polar Team. The exercise was performed at the intensity of 69% of the maximal heart rate and the mean heart rate of 112 bpm of the subjects for 45 min. The physical activity level was increased from the beginning (2303.4 MET·min/week) to the end (3634.7 MET·min/week) of training program according to IPAQ survey, though no statistical difference was found. Furthermore, following the group interview, overall positive responses were reported regarding physical and mental health improvements.

Conclusion: This study may be served as base and will be helpful in developing a high intensity interval training for the breast cancer survivors.